A novel leukoencephalopathy associated with tau deposits primarily in white matter glia

@article{Powers2003ANL,
  title={A novel leukoencephalopathy associated with tau deposits primarily in white matter glia},
  author={J Michael Powers and Niall P Byrne and Masayuki Ito and Masaki Takao and D. Yankopoulou and Maria Grazia Spillantini and Bernardino Ghetti},
  journal={Acta Neuropathologica},
  year={2003},
  volume={106},
  pages={181-187}
}
A 79-year-old woman had a 10-year history of dementia, initially presenting as non-fluent aphasia. Magnetic resonance imaging showed frontal atrophy (left greater than right) and hyperintense foci within white matter. Neuropathologically, there was severe frontal atrophy due to cortical neuronal loss with spongy change and to an even greater loss of white matter that contained prominent eosinophilic deposits. The deposits were immunoreactive for phosphorylated tau, non-reactive for Aβ and… CONTINUE READING
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