A novel large dermatan sulfate proteoglycan from human fibroblasts.

  title={A novel large dermatan sulfate proteoglycan from human fibroblasts.},
  author={Beate Breuer and E. Quentin and Z Cully and Matthias G{\"o}tte and Hans Kresse},
  journal={The Journal of biological chemistry},
  volume={266 20},
Human skin fibroblasts express, in addition to versican, a second large chondroitin sulfate/dermatan sulfate proteoglycan, which has been investigated with the aid of a specific antiserum in cultures of fetal fibroblasts. Its core protein, obtained after chondroitin ABC lyase treatment, exhibits an apparent molecular mass of about 740 kDa in the absence of a reducing agent whereas reduction produces two core proteins of 460 and 300 kDa, respectively. Both subunits carry one or very few dermatan… CONTINUE READING