A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina.

@article{Andr1998ANI,
  title={A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina.},
  author={Eunice Andr{\'e} and K Gawlas and M Becker-Andr{\'e}},
  journal={Gene},
  year={1998},
  volume={216 2},
  pages={277-83}
}
RORbeta is a member of the nuclear hormone receptor superfamily whose ligand is unknown. Expression of RORbeta is confined to the central nervous system and its pattern suggests that this orphan nuclear receptor is implicated in the processing of sensory information and in circadian timing. In rats, RORbeta mRNA levels oscillate robustly in pineal gland and retina, displaying a 24h rhythm. Here we report the cloning of the cDNA of a novel isoform of RORbeta from rat pineal tissue. Expression of… CONTINUE READING

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