A novel irreversible antagonist of the A1-adenosine receptor.

@article{Srinivas1996ANI,
  title={A novel irreversible antagonist of the A1-adenosine receptor.},
  author={Miduturu Srinivas and John C. Shryock and Peter J. Scammells and J. Craig Ruble and Stephen P. Baker and Luiz Belardinelli},
  journal={Molecular pharmacology},
  year={1996},
  volume={50 1},
  pages={196-205}
}
We determined the effects of 8-cyclopentyl-3-[3-[[4-(fluorosulfonyl)benzoyl]oxy]propyl]-1-propylxanth ine (FSCPX), a putative irreversible antagonist of the A1-adenosine receptor, on cardiac A1-adenosine receptor-mediated responses and on the specific binding of [3H]-8-cyclopentyl-1,3-dipropylxanthine ([3H]CPX) to guinea pig cardiac and brain membranes. FSCPX (5 microM) completely reversed the increase in K+ current of guinea pig atrial myocytes caused by 100 microM adenosine (259 +/- 30 to 20… CONTINUE READING
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