A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers

  title={A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers},
  author={Xiuchao Wang and Shan Wang and Wen-ting Wang and Jianhong Duan and Ming Zhang and Xiaohua Lv and Chunxiao Niu and Chao Tan and Yuanbin Wu and Jing Yang and Sanjue Hu and Junling Xing},
  pages={2235 - 2247}
Abstract Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic neuropathy. In this study, we extend this finding in the complete Freund's adjuvant model of inflammatory pain and validate that the degree of conduction failure… 
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