A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers

@article{Wang2016ANI,
  title={A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers},
  author={Xiuchao Wang and Shan Wang and Wen-ting Wang and Jianhong Duan and Ming Zhang and Xiaohua Lv and Chunxiao Niu and Chao Tan and Yuanbin Wu and Jing Yang and Sanjue Hu and Junling Xing},
  journal={Pain},
  year={2016},
  volume={157},
  pages={2235 - 2247}
}
Abstract Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic neuropathy. In this study, we extend this finding in the complete Freund's adjuvant model of inflammatory pain and validate that the degree of conduction failure… 
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References

SHOWING 1-10 OF 48 REFERENCES
Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats.
TLDR
It is shown that conduction of action potential can fail to occur in response to repetitive activity when they travel down the main axon of polymodal nociceptive C-fibres, and a novel mechanism underlying diabetic hyperalgesia is revealed.
HCN2 ion channels: an emerging role as the pacemakers of pain.
Neuronal Hyperpolarization-Activated Pacemaker Channels Drive Neuropathic Pain
TLDR
It is demonstrated that hyperpolarization-activated, cyclic nucleotide-modulated (HCN) “pacemaker” channels play a previously unrecognized role in both touch-related pain and spontaneous neuronal discharge originating in the damaged dorsal root ganglion.
Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation
TLDR
The data suggest that joint damage can lead to changes in the fidelity of AP conduction of large diameter sensory neurons, muscle spindle neurons in particular, arising from articular and nonarticular tissues in OA animals compared to controls.
Axonal voltage-gated ion channels as pharmacological targets for pain.
...
...