A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models

@inproceedings{Amici2016ANI,
  title={A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models},
  author={Carla Amici and Michela Visintin and Francesca Verachi and Francesca Paolini and Zulema Antonia Percario and Paola di Bonito and Angela Mandarino and Elisabetta Affabris and Aldo Venuti and L Accardi},
  booktitle={Oncotarget},
  year={2016}
}
Single-chain variable fragments (scFvs) expressed as "intracellular antibodies" (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. Here we use an intrabody targeting the E6 oncoprotein of Human papillomavirus 16 (HPV16) to address the issue of a non-invasive therapy for HPV cancer patients.A scFv against the HPV16 E6 was selected by Intracellular Antibody Capture Technology and expressed as I7nuc in the nucleus of HPV16-positive SiHa, HPV… CONTINUE READING
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