A novel interaction of cGMP-dependent protein kinase I with troponin T.

@article{Yuasa1999ANI,
  title={A novel interaction of cGMP-dependent protein kinase I with troponin T.},
  author={Keizo Yuasa and Hideo Michibata and Kenji Omori and Noriyuki Yanaka},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 52},
  pages={37429-34}
}
cGMP-dependent protein kinase (cGK) is a major intracellular receptor of cGMP and is implicated in several signal transduction pathways. To identify proteins that participate in the cGMP/cGK signaling pathway, we employed the yeast two-hybrid system with cGK Ialpha as bait. cDNAs encoding slow skeletal troponin T (skTnT) were isolated from both mouse embryo and human skeletal muscle cDNA libraries. The skTnT protein interacted with cGK Ibeta but not with cGK II nor cAMP-dependent protein kinase… CONTINUE READING
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