A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation.

@article{Miura2002ANI,
  title={A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation.},
  author={Masako Miura and Kiyoshi Tanaka and Yasato Komatsu and Michio Suda and Akihiro Yasoda and Yoko Sakuma and Ami Ozasa and Kazuwa Nakao},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={291 4},
  pages={987-94}
}
Thyroid hormones enhance osteoclast formation and their excess is an important cause of secondary osteoporosis. 3,5,3' -Triiodo-L-thyronine (T3) induced the mRNA expression of receptor activator of nuclear factor-kappa B ligand (RANKL), which is a key molecule in osteoclast formation, in primary osteoblastic cells (POB). This effect was amplified in the copresence of 1 alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)). Although T3 alone did not induce octeoclasts in coculture of bone marrow… CONTINUE READING
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