A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.

@article{Long2013ANI,
  title={A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.},
  author={Tingting Long and Juan Su and Wen Lu Tang and Zhongling Luo and Shuang Liu and Zhaoqian Liu and Honghao Zhou and Min Qi and Weiqi Zeng and Jianglin Zhang and Xiang Chen},
  journal={Cancer letters},
  year={2013},
  volume={339 1},
  pages={93-101}
}
Intracellular free calcium is a ubiquitous second messenger regulating a multitude of normal and pathogenic cellular responses, including the development of melanoma. Upstream signaling pathways regulating the intracellular free calcium concentration ([Ca2+]i) may therefore have a significant impact on melanoma growth and metastasis. In this study, we demonstrate that the endoplasmic reticulum (ER)-associated protein calcium-modulating cyclophilin ligand (CAML) is bound to Basigin, a widely… CONTINUE READING
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