A novel interaction between aging and ER overload in a protein conformational dementia.

@article{Schipanski2013ANI,
  title={A novel interaction between aging and ER overload in a protein conformational dementia.},
  author={Angela Schipanski and Sascha Lange and Alexandra Segref and Aljona Gutschmidt and David A. Lomas and Elena Miranda and Michaela Schweizer and Thorsten Hoppe and Markus Glatzel},
  journal={Genetics},
  year={2013},
  volume={193 3},
  pages={865-76}
}
Intraneuronal deposition of aggregated proteins in tauopathies, Parkinson disease, or familial encephalopathy with neuroserpin inclusion bodies (FENIB) leads to impaired protein homeostasis (proteostasis). FENIB represents a conformational dementia, caused by intraneuronal polymerization of mutant variants of the serine protease inhibitor neuroserpin. In contrast to the aggregation process, the kinetic relationship between neuronal proteostasis and aggregation are poorly understood. To address… CONTINUE READING

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