A novel intein-like autoproteolytic mechanism in autotransporter proteins.

@article{Tajima2010ANI,
  title={A novel intein-like autoproteolytic mechanism in autotransporter proteins.},
  author={Nami Tajima and Fumihiro Kawai and S -J Park and Jeremy R. H. Tame},
  journal={Journal of molecular biology},
  year={2010},
  volume={402 4},
  pages={645-56}
}
Many virulence factors secreted by pathogenic Gram-negative bacteria are found to be members of the autotransporter protein family. These proteins share a common mechanism by which they exit the periplasm, involving the formation of a 12-stranded β-barrel domain in the outer membrane. The role of this barrel in the secretion of the N-terminal passenger domain is controversial, and no model currently explains satisfactorily the entire body of experimental data. After secretion, some… CONTINUE READING

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Crystal structure of a fulllength autotransporter

  • B. van den Berg
  • J. Mol. Biol
  • 2010
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