A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates.

@article{He1999ANI,
  title={A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates.},
  author={Tian Jin He and Tatsuji Nishihara and Donald R Demuth and Isao Ishikawa},
  journal={Journal of periodontology},
  year={1999},
  volume={70 11},
  pages={1261-8}
}
BACKGROUND The expression of leukotoxin varies among Actinobacillus actinomycetemcomitans strains and is dependent in part on the structure of the ltx promoter region. Highly leukotoxic strains, characterized by a 530 base pair (bp) deletion within the ltx promoter, have been associated with juvenile periodontitis in the United States and Europe. In the present study, we analyzed the ltx promoter structure to elucidate whether A. actinomycetemcomitans from Japanese periodontitis patients… CONTINUE READING

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