A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone

@article{Cui2014ANI,
  title={A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone},
  author={Xu Cui and Cunju Zhao and Yifei Gu and Le Li and Hui Wang and Wenhai Huang and Nai Fu Zhou and Deping Wang and Yi Zhu and Jun Xu and Shihua Luo and Changqing Zhang and Mohamed N. Rahaman},
  journal={Journal of Materials Science: Materials in Medicine},
  year={2014},
  volume={25},
  pages={733-745}
}
Osteomyelitis (bone infection) is often difficult to cure. The commonly-used treatment of surgical debridement to remove the infected bone combined with prolonged systemic and local antibiotic treatment has limitations. In the present study, an injectable borate bioactive glass cement was developed as a carrier for the antibiotic vancomycin, characterized in vitro, and evaluated for its capacity to cure osteomyelitis in a rabbit tibial model. The cement (initial setting time = 5.8 ± 0.6 min… CONTINUE READING
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