A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

  title={A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death},
  author={Tabitha E. Wood and S. Dalili and Craig D. Simpson and R. Hurren and X. Mao and Fernando Jose Suarez Saiz and M. Gronda and Yanina Eberhard and M. Minden and P. Bilan and A. Klip and R. Batey and A. Schimmer},
  journal={Molecular Cancer Therapeutics},
  pages={3546 - 3555}
  • Tabitha E. Wood, S. Dalili, +10 authors A. Schimmer
  • Published 2008
  • Biology, Medicine
  • Molecular Cancer Therapeutics
  • Evasion of death receptor ligand-induced apoptosis is an important contributor to cancer development and progression. Therefore, molecules that restore sensitivity to death receptor stimuli would be important tools to better understand this biological pathway and potential leads for therapeutic adjuncts. Previously, the small-molecule N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide (fasentin) was identified as a chemical sensitizer to the death receptor stimuli FAS and tumor necrosis… CONTINUE READING
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