A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains co-occurrence

@inproceedings{Canisius2016ANI,
  title={A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains co-occurrence},
  author={Sander Canisius and John W. M. Martens and A. LodewykF. and L F A Wessels},
  year={2016}
}
Just like recurrent somatic alterations characterize cancer genes, mutually exclusive or co-occurring alterations across genes suggest functional interactions. Identifying such patterns in large cancer studies thus helps the discovery of unknown interactions. Many studies use Fisher’s exact test or simple permutation procedures for this purpose. These tests assume identical gene alteration probabilities across tumors, which is not true for cancer. We show that violating this assumption yields… CONTINUE READING