A novel in vitro model for the study of plaque development in atherosclerosis.

  title={A novel in vitro model for the study of plaque development in atherosclerosis.},
  author={Bernhard Dorweiler and Michael Torzewski and Manfred Dr Dahm and Viola Ochsenhirt and Hans Anton Lehr and Karl J. Lackner and Christian-Friedrich Vahl},
  journal={Thrombosis and haemostasis},
  volume={95 1},
For the study of atherogenesis in vitro, coculture systems have been devised, in which two or more cell types can be cultured in close contact to each other. Herein, we describe a novel in vitro model that aims at the simulation of the morphology of a normal muscular artery allowing for the study of the initial events in atherosclerosis. Using a modified fibrin gel as a scaffold for the coculture of endothelial cells (ECs) and smooth muscle cells (SMCs), we generated an autologous in vitro… 

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