A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification.

@article{Guicheux2000ANI,
  title={A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification.},
  author={J{\'e}r{\^o}me Guicheux and Gaby Palmer and Chisa Shukunami and Yuji Hiraki and J. P. Bonjour and Joseph Caverzasio},
  journal={Bone},
  year={2000},
  volume={27 1},
  pages={69-74}
}
In vivo expression of the type III sodium-dependent phosphate transporter (NaPiT) Glvr-1 during endochondral ossification, suggests a functional role for inorganic phosphate (Pi) transport in cartilage calcification. For further analysis of this relationship, an in vitro model of endochondral ossification is required. In this context, we investigated the characteristics of Pi transport in the new chondrogenic cell line ATDC5 in relation to extracellular matrix (ECM) formation and mineralization… CONTINUE READING

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