A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma

@article{Dring2014ANI,
  title={A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma},
  author={Claudia D{\"o}ring and Martin-Leo Hansmann and Claudio Agostinelli and Pier Paolo Piccaluga and Fabio F. Facchetti and Stefano A Pileri and Ralf K{\"u}ppers and Sebastian Newrzela and Sylvia Hartmann},
  journal={Modern Pathology},
  year={2014},
  volume={27},
  pages={1345-1354}
}
Classical Hodgkin lymphoma and ALK− anaplastic large cell lymphoma share many features like strong CD30 expression and usually loss of B- and T-cell markers. However, their clinical course is dramatically different with curability rates of >90% for classical Hodgkin lymphoma and an unfavorable prognosis for anaplastic large cell lymphoma. Classical Hodgkin lymphoma and ALK− anaplastic large cell lymphoma can usually be distinguished by PAX5 expression in the Hodgkin and Reed-Sternberg cells of… CONTINUE READING