A novel immunocompetent murine model for replicating oncolytic adenoviral therapy

@inproceedings{Zhang2015ANI,
  title={A novel immunocompetent murine model for replicating oncolytic adenoviral therapy},
  author={Lei Zhang and Farah Hedjran and Caroline Larson and Gilda Lemos P{\'e}rez and Tony R. Reid},
  booktitle={Cancer Gene Therapy},
  year={2015}
}
Oncolytic adenoviruses are under investigation as a promising novel strategy for cancer immunotherapeutics. Unfortunately, there is no immunocompetent mouse cancer model to test oncolytic adenovirus because murine cancer cells are generally unable to produce infectious viral progeny from human adenoviruses. We find that the murine K-ras-induced lung adenocarcinoma cell line ADS-12 supports adenoviral infection and generates infectious viral progeny. ADS-12 cells express the coxsackie and… CONTINUE READING

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