A novel immune-to-CNS communication pathway: Cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus

@article{WieselerFrank2007ANI,
  title={A novel immune-to-CNS communication pathway: Cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus},
  author={Julie Wieseler-Frank and Brian M. Jekich and John H. Mahoney and Sondra T. Bland and Linda R. Watkins},
  journal={Brain, Behavior, and Immunity},
  year={2007},
  volume={21},
  pages={711-718}
}
Pain is enhanced in response to elevations of proinflammatory cytokines in spinal cerebrospinal fluid (CSF), following either intrathecal injection of these cytokines or intrathecal immune challenge with HIV-1 gp120 that induces cytokine release. Spinal cord glia have been assumed to be the source of endogenous proinflammatory cytokines that enhance pain. However, assuming that spinal cord glia are the sole source of CSF cytokines may be an underestimate, as the cellular composition of the… CONTINUE READING

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