A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.

@article{Pike2013ANH,
  title={A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.},
  author={Adrianne F Pike and Nynke I. Kramer and Bas J. Blaauboer and Willem Seinen and R. M. Munoz Brands},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 12},
  pages={2044-56}
}
The liver isoform of the enzyme alkaline phosphatase (AP) has been used classically as a serum biomarker for hepatic disease states such as hepatitis, steatosis, cirrhosis, drug-induced liver injury, and hepatocellular carcinoma. Recent studies have demonstrated a more general anti-inflammatory role for AP, as it is capable of dephosphorylating potentially deleterious molecules such as nucleotide phosphates, the pathogenic endotoxin lipopolysaccharide (LPS), and the contact clotting pathway… CONTINUE READING
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