A novel human tumor necrosis factor alfa mutein, F4614, inhibits in vitro and in vivo growth of murine and human hepatoma: Implication for immunotherapy of human hepatocellular carcinoma

@article{Atarashi1998ANH,
  title={A novel human tumor necrosis factor alfa mutein, F4614, inhibits in vitro and in vivo growth of murine and human hepatoma: Implication for immunotherapy of human hepatocellular carcinoma},
  author={Yoshinari Atarashi and Satoshi Yasumura and Shuji Nambu and Yuko Yoshio and Jun Murakami and Toshio Takahara and Kiyohiro Higuchi and Akiharu Watanabe and Keizo Miyata and M. Kato},
  journal={Hepatology},
  year={1998},
  volume={28}
}
Although treatment for hepatocellular carcinoma (HCC) has recently improved, most patients still relapse and die from this disease. The development of new therapeutic and preventive strategies for HCC is, therefore, required. A novel mutant protein (mutein) of human tumor necrosis factor alfa (TNF‐α mutein F4614,1SSSRGDSD··· 29V ··· 155L) was developed to decrease several adverse effects of TNF‐α. F4614 is known to lack hypotensive effects of human TNF‐α without losing its anti‐tumor effect in… Expand
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