A novel human stress response-related gene with a potential role in induced radioresistance.

@article{Robson1999ANH,
  title={A novel human stress response-related gene with a potential role in induced radioresistance.},
  author={Tracy Robson and Michael C. Joiner and George D. Wilson and William M. McCullough and Monroe E. Price and Ian D Logan and Huw Kiss Jones and Stephanie R. McKeown and David Graham Hirst},
  journal={Radiation research},
  year={1999},
  volume={152 5},
  pages={451-61}
}
We have isolated a novel gene, DIR1, from L132 cells that is transiently repressed after exposure to low radiation doses and has a potential role in induced radioresistance. Molecular and cellular characterization of this gene reveals that it is unique but has similarities to a family of heat-shock-related proteins known as immunophilins. These have been implicated in various cellular functions including general stress responses and control of the cell cycle. Antisense strategies have… CONTINUE READING