A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization.

@article{Wang2004ANH,
  title={A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization.},
  author={Xiaojian Wang and Nan Li and Bin Liu and Hongying Sun and Taoyong Chen and Hongzhe Li and Jianming Qiu and Lihuang Zhang and Tao Wan and Xuetao Cao},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 44},
  pages={45855-64}
}
The phosphatidylethanolamine (PE)-binding proteins (PEBPs) are an evolutionarily conserved family of proteins with pivotal biological functions. Here we describe the cloning and functional characterization of a novel family member, human phosphatidylethanolamine-binding protein 4 (hPEBP4). hPEBP4 is expressed in most human tissues and highly expressed in tumor cells. Its expression in tumor cells is further enhanced upon tumor necrosis factor (TNF) alpha treatment, whereas hPEBP4 normally co… CONTINUE READING