A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.

Abstract

Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy. Despite the significant clinical burden, little progress has been made in terms of therapeutic development. A unique approach to identifying new human-validated analgesic drug targets is to study rare families with… (More)
DOI: 10.1093/brain/awx326

Cite this paper

@article{Habib2017ANH, title={A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.}, author={Abdella M. Habib and Ayako Matsuyama and Andrei L. Okorokov and Sonia Santana-Varela and Jose T Bras and Anna Maria Aloisi and Edward C. Emery and Yury D Bogdanov and Maryne Follenfant and Sam J Gossage and Mathilde Gras and Jack Humphrey and Anna Kolesnikov and Kim Le Cann and Shengnan Li and Michael S. Minett and Vanessa Pereira and Clara Ponsolles and Shafaq Sikandar and Jes{\'u}s M. Torres and Kenji Yamaoka and Jing Zhao and Yuriko Komine and Tetsuo Yamamori and Nikolas Maniatis and Konstantin I. Panov and Henry Houlden and Juan D Ramirez and David L. H. Bennett and Letizia Marsili and Valeria Bachiocco and John N Wood and James J. Cox}, journal={Brain : a journal of neurology}, year={2017} }