A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

@article{Wang2004ANH,
  title={A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.},
  author={Shuwen Wang and Gavin P Robertson and Jiyue Zhu},
  journal={Gene},
  year={2004},
  volume={343 1},
  pages={69-78}
}
Polycomb group (PcG) proteins function to maintain the stable epigenetic repression of homeotic genes and other important developmental and cell cycle regulatory genes. Such maintenance establishes a form of cellular memory for its identity or state of differentiation. Accumulating evidence indicates that perturbation of this transcriptional memory may be required for tumor progression and may represent a hallmark of cancer. We have identified a novel gene encoding a human homologue of the… CONTINUE READING

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