A novel human homolog of eosinophil major basic protein.

  title={A novel human homolog of eosinophil major basic protein.},
  author={Douglas A. Plager and Cheryl R Adolphson and Gerald J. Gleich},
  journal={Immunological reviews},
Eosinophil major basic protein (MBP) contributes to host defense and disease pathophysiology. Chromosome 11 contains the genes for human MBP1 (hMBP1) and a second novel MBP, hMBP2, in the centromere to 11q12 region. Interestingly, greater similarity exists between human and murine MBP1 and MBP2 orthologs, respectively, than between hMBP1 and hMBP2, suggesting a gene duplication event prior to the divergence of humans and mice. There is abundant mRNA for hMBP1 in both bone marrow (eosinophils… CONTINUE READING