A novel human RasGAP‐like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25

@article{Noto1998ANH,
  title={A novel human RasGAP‐like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25},
  author={Satoshi Noto and Tatsuya Maeda and Seisuke Hattori and Johji Inazawa and Masahiro Imamura and Masahiro Asaka and Masanori Hatakeyama},
  journal={FEBS Letters},
  year={1998},
  volume={441}
}
Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate.
TLDR
It appears that epigenetic regulation, particularly histone acetylation of the Dab2ip gene promoter, plays an important role in modulating its gene expression in the mouse prostate cancer cell.
The Human RNA Helicase A (DDX9) Gene Maps to the Prostate Cancer Susceptibility Locus at Chromosome Band 1q25 and Its Pseudogene (DDX9P) to 13q22, Respectively
TLDR
The human RNA helicase A ( DDX9) gene is mapped to the major susceptibility locus for prostate cancer at chromosome band 1q25, and its pseudogene (DDX9P) to the band 13q22 by fluorescence in situ hybridization, somatic cell hybrid analysis, and assignment of YAC clones, respectively.
Identification of a novel RAS GTPase‐activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia
TLDR
The identification of this RASGAP protein in a novel MLL fusion implies that an indirect RAS‐deregulating mechanism could be involved in leukemic transformation.
Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization.
TLDR
It is demonstrated that normal prostatic epithelial cells have elevated DAB2IP mRNA compared with cancer cells, which correlates with increased DAB 2IP promoter activity, which indicates that transcriptional regulation of DAB1/2 is responsible for the downregulation of Dab2IP expression in prostate cancer cells.
Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis
TLDR
The role of individual RasGAP family members in normal tissue and in disease is discussed, including critical nonredundant functions for each RasG AP in tissue homeostasis and as regulators of disease processes in mouse and man.
Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
TLDR
The results suggest that the inhibition of p38 could predispose human cells to partial transformation by oncogenic Ras through alterations in cellular adhesion.
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer
TLDR
The data indicate that RASAL2 is a tumor suppressor in BCa, and modulates cancer stemness and EMT for BCa recurrence and metastasis.
Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes.
TLDR
It is estimated that their ancestors had small sizes of small GTPases and GAPs and their large-scale expansions occurred after the divergence from their ancestors, and genome duplications represented the major mechanism for such expansions.
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It is suggested that mutant NF1-GRDs may bind tightly to transforming Ras, which stays in GTP-bound conformation, thus preventing the interaction with the putative effector molecule.
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