A novel human RasGAP‐like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25

  title={A novel human RasGAP‐like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25},
  author={Satoshi Noto and Tatsuya Maeda and Seisuke Hattori and Johji Inazawa and Masahiro Imamura and Masahiro Asaka and Masanori Hatakeyama},
  journal={FEBS Letters},
Cloning of mouse Dab2ip gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region in prostate.
It appears that epigenetic regulation, particularly histone acetylation of the Dab2ip gene promoter, plays an important role in modulating its gene expression in the mouse prostate cancer cell.
The Human RNA Helicase A (DDX9) Gene Maps to the Prostate Cancer Susceptibility Locus at Chromosome Band 1q25 and Its Pseudogene (DDX9P) to 13q22, Respectively
The human RNA helicase A ( DDX9) gene is mapped to the major susceptibility locus for prostate cancer at chromosome band 1q25, and its pseudogene (DDX9P) to the band 13q22 by fluorescence in situ hybridization, somatic cell hybrid analysis, and assignment of YAC clones, respectively.
Identification of a novel RAS GTPase‐activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia
The identification of this RASGAP protein in a novel MLL fusion implies that an indirect RAS‐deregulating mechanism could be involved in leukemic transformation.
Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization.
It is demonstrated that normal prostatic epithelial cells have elevated DAB2IP mRNA compared with cancer cells, which correlates with increased DAB 2IP promoter activity, which indicates that transcriptional regulation of DAB1/2 is responsible for the downregulation of Dab2IP expression in prostate cancer cells.
Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis
The role of individual RasGAP family members in normal tissue and in disease is discussed, including critical nonredundant functions for each RasG AP in tissue homeostasis and as regulators of disease processes in mouse and man.
Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
The results suggest that the inhibition of p38 could predispose human cells to partial transformation by oncogenic Ras through alterations in cellular adhesion.
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer
The data indicate that RASAL2 is a tumor suppressor in BCa, and modulates cancer stemness and EMT for BCa recurrence and metastasis.
Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes.
It is estimated that their ancestors had small sizes of small GTPases and GAPs and their large-scale expansions occurred after the divergence from their ancestors, and genome duplications represented the major mechanism for such expansions.


Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
It is suggested that mutant NF1-GRDs may bind tightly to transforming Ras, which stays in GTP-bound conformation, thus preventing the interaction with the putative effector molecule.
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
Evidence is presented that the ras proteins in malignant tumour cell lines from patients with type 1 neurofibromatosis are in a constitutively activated state, as judged by the guanine nucleotide bound to them, and are necessary for cellular proliferation, and support the hypothesis that NF1 is a tumour-suppressor gene whose product acts upstream of ras.
Characterization of the C. elegans gap‐2 gene encoding a novel Ras‐GTPase activating protein and its possible role in larval development
A new GAP gene is isolated from C. elegans by transcomplementation of the fission yeast gap1 mutant to aid the study of the regulation and function of the Ras pathway.
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.
Proper ras1 function is required for normal sexual function in the yeast Schizosaccharomyces pombe. We have found a gene in S. pombe, sar1, that encodes a product capable of regulating ras1 function.
ras oncogenes in human cancer: a review.
  • J. Bos
  • Biology, Medicine
    Cancer research
  • 1989
It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly and some evidence that environmental agents may be involved in the induction of the mutations.
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.
The results suggest that the IRA1 protein inhibits the function of the RAS proteins in a fashion antagonistic to thefunction of the CDC25 protein in the Ras-cyclic AMP pathway in Saccharomyces cerevisiae.