A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells.

@article{Lindvall2004ANH,
  title={A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells.},
  author={H{\aa}kan Lindvall and Pernilla Nevsten and Kristoffer Str{\"o}m and Reine L Wallenberg and Frank Sundler and Dominique Langin and Maria S{\"o}rhede Winzell and Cecilia Holm},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 5},
  pages={3828-36}
}
Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in many cell types. Two isoforms of HSL are known to date, namely HSL(adi) (84 kDa in rat) and HSL(tes) (130 kDa in rat). These are encoded by the same gene, with exons 1-9 encoding the parts that are common to both and an additional 5'-exon encoding the additional amino acids in HSL(tes). HSL of various tissues, among these the islet of Langerhans, is larger than HSL(adi), but not as large as HSL(tes), indicating that… CONTINUE READING