A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.

  title={A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.},
  author={Yasutsugu Yamanaka and Takafumi Mizuno and Yoshiki Sasai and Masashi Kishi and Hiroyuki Takeda and Chang Hyun Kim and Masahiko Hibi and Takeshi Hirano},
  journal={Genes & development},
  volume={12 15},
The formation of Spemann organizer is one of the most important steps in dorsoventral axis determination in vertebrate development. However, whether the organizer forms autonomously or is induced non-cell-autonomously is controversial. In this report we have isolated a novel zebrafish homeobox gene, dharma, capable of inducing the organizer ectopically. The expression of dharma was first detected in several blastomeres at one side of the margin soon after the mid-blastula transition and… CONTINUE READING
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Tates and roles of the presumptive organizer region in the 32 - cell embryo in normal development of Xenopus laevis

  • M. Westerfield
  • Dev . Growth Differ .
  • 1995
Highly Influential
3 Excerpts

A molecular mechanism for the action of lithium during early development

  • M. Torres, B. A. Rowning, +4 authors R. T. Moon
  • Proc . Natl . Acad . Sci .
  • 1997

Establishment of the dorsoventral axis in Xenopus embryos is presaged by early asymmetries in beta - catenin that are modulated by the Wnt signaling pathway

  • I. L. Blitz, C. Hashimoto, U. Rothbacher
  • J . Cell Biol .
  • 1997

A role for cytoplasmic determinants in mesoderm patterning : Cell - autonomous activation of the goosecoid and Xwnt - 8 genes along the dorsoventral axis of early Xenopus embryos

  • L. Kodjabachian
  • Development
  • 1996
1 Excerpt

Ectodermal patterning in vertebrate embryos

  • H. Steinbeisser, R. M. Warga, P. Hausen
  • Dev . Biol .
  • 1996

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