A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.

@article{Yamanaka1998ANH,
  title={A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.},
  author={Yasutsugu Yamanaka and Takafumi Mizuno and Yoshiki Sasai and Masashi Kishi and Hiroyuki Takeda and Chang Hyun Kim and Masahiko Hibi and Takeshi Hirano},
  journal={Genes & development},
  year={1998},
  volume={12 15},
  pages={2345-53}
}
The formation of Spemann organizer is one of the most important steps in dorsoventral axis determination in vertebrate development. However, whether the organizer forms autonomously or is induced non-cell-autonomously is controversial. In this report we have isolated a novel zebrafish homeobox gene, dharma, capable of inducing the organizer ectopically. The expression of dharma was first detected in several blastomeres at one side of the margin soon after the mid-blastula transition and… CONTINUE READING
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