A novel heme protein, the Cu,Zn-superoxide dismutase from Haemophilus ducreyi.

@article{Pacello2001ANH,
  title={A novel heme protein, the Cu,Zn-superoxide dismutase from Haemophilus ducreyi.},
  author={Francesca Pacello and Paul R Langford and J. Simon Kroll and Chiara Indiani and Giulietta Smulevich and Alessandro Desideri and Giuseppe Rotilio and Andrea Battistoni},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={30326-34}
}
Haemophilus ducreyi, the causative agent of the genital ulcerative disease known as chancroid, is unable to synthesize heme, which it acquires from humans, its only known host. Here we provide evidence that the periplasmic Cu,Zn-superoxide dismutase from this organism is a heme-binding protein, unlike all the other known Cu,Zn-superoxide dismutases from bacterial and eukaryotic species. When the H. ducreyi enzyme was expressed in Escherichia coli cells grown in standard LB medium, it contained… CONTINUE READING
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