A novel hamster prion protein mRNA contains an extra exon: increased expression in scrapie.

@article{Li1997ANH,
  title={A novel hamster prion protein mRNA contains an extra exon: increased expression in scrapie.},
  author={Guiying Li and David Chas Bolton},
  journal={Brain research},
  year={1997},
  volume={751 2},
  pages={265-74}
}
Prion protein (PrP) is the only known constituent of the agents (called prions) that cause fatal neurodegenerative diseases in animals and humans. PrP derives from a host protein encoded by a single copy gene having three known exons in mice, cattle and sheep but only two exons in hamsters and humans. We have identified and sequenced the missing exon from the hamster PrP gene. The new hamster PrP exon is 83% identical to mouse exon 2 and 76% identical to exon 2 from cattle and sheep. PrP mRNAs… CONTINUE READING