A novel glyco-conjugate vaccine against fungal pathogens

@article{Torosantucci2005ANG,
  title={A novel glyco-conjugate vaccine against fungal pathogens},
  author={Antonella Torosantucci and Carla Bromuro and Paola Chiani and Flavia de Bernardis and Francesco Berti and Chiara Galli and Francesco Norelli and Cinzia Bellucci and Luciano Polonelli and Paolo Costantino and Rino Rappuoli and Antonio Cassone},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={597 - 606}
}
To generate a vaccine to protect against a variety of human pathogenic fungi, we conjugated laminarin (Lam), a well-characterized but poorly immunogenic beta-glucan preparation from the brown alga Laminaria digitata, with the diphtheria toxoid CRM197, a carrier protein used in some glyco-conjugate bacterial vaccines. This Lam-CRM conjugate proved to be immunogenic and protective as immunoprophylactic vaccine against both systemic and mucosal (vaginal) infections by Candida albicans. Protection… CONTINUE READING

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