A novel glucocorticoid regulatory unit mediates the hormone responsiveness of the beta1-adrenergic receptor gene.

@article{Tseng2001ANG,
  title={A novel glucocorticoid regulatory unit mediates the hormone responsiveness of the beta1-adrenergic receptor gene.},
  author={Y T Tseng and Joan P Stabila and Tam Thuan Nguyen and Bethany G. McGonnigal and James A. Waschek and James Padbury},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={181 1-2},
  pages={165-78}
}
The effects of glucocorticoids on expression of the beta1-adrenergic receptor (beta1AR) gene have been varied. To study the mechanism underling hormonal regulation of the beta1AR, transient transfection of progressively deleted ovine beta1AR promoter fragments was used to identify a 43-bp region (-1274 to -1232 from the translation start site) that contains a novel glucocorticoid regulatory unit (GRU) and confers glucocorticoid responsiveness. Using DNase I footprinting and electrophoretic… CONTINUE READING

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