A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family

@article{Hamada2000ANG,
  title={A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family},
  author={Tsuyoshi Hamada and Kumiko Ui-Tei and Yuhei Miyata},
  journal={FEBS Letters},
  year={2000},
  volume={475}
}
Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.
TLDR
A novel gene homologous to SCDGF/PDGF-C/fallotein is isolated, and namedSCDGF-B, which was categorized into a new subfamily in addition to PDGF and VEGF subfamilies.
Developmental roles of platelet‐derived growth factors
TLDR
The present review summarizes and discusses the biological functions of PDGFs andPDGFRs in developmental processes, mainly as revealed through genetic analysis in mice, and suggests that ancestral PDGF and PDGFR expression patterns and functions may have been iterated in related sets of morphogenetic processes in the course of evolution.
Roles of PDGF in animal development
TLDR
Early data from different systems suggest that some functions of PDGFs have been evolutionarily conserved, and the availability of genomic sequence data has facilitated the identification of novel PDGF and PDGF receptor (PDGFR) family members in C. elegans, Drosophila, Xenopus, zebrafish and mouse.
The Molecular Cloning of Platelet-Derived Growth Factor-C (PDGF-C) Gene of Gekko japonicus and Its Expression Change in the Spinal Cord After Tail Amputation
TLDR
The expression of PDGF-C in the spinal cord showed highest level at 1 day after tail amputation, and gradually decreased until 2 weeks, which indicated that the expression level of PD GF-C might be associated with the process of spinal cord injury and regeneration.
PII: S0925-4773(01)00625-6
TLDR
In the rat central nervous system, the expression of SCDGF/PDGF-C/fallotein was more remarkable at E16 than at adult, and it was highly expressed in the cortex, pontine area and choroid plexus at E 16.
Platelet-derived growth factor signaling and human cancer.
TLDR
Important features of the PDGF isoforms and their cell surface receptor subunits are discussed, with regards to signal transduction, PDGF-isoform specific cellular responses, and involvement in angiogensis, and tumorstromal interactions.
Biological activities of novel Platelet-derived growth factors, PDGF-C and PDGF-D
TLDR
It is suggested that PDGF-C andPDGF-D are potent modulators of vascular growth, as well as powerful mitogens for connective tissue cells for therapeutic angiogenesis and to recruit mural cells.
The Role of Platelet-Derived Growth Factor C and Its Splice Variant in Breast Cancer
TLDR
Data in vitro and in vivo show that higher expression of the PDGFC isoforms in breast cancer cell lines is associated with higher proliferation, invasion, and metastatic potential, and future drug targeting may need to take into account the intracellular and extracellular roles of both PDG FC isoform in order to combat cancer.
Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer.
TLDR
Detailed and systematic PDGF D transcript analysis revealed expression in many cell lines derived from ovarian, renal, and lung cancers, as well as from astrocytomas and medulloblastomas, and suggested autocrine signaling in several brain tumor cell lines.
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