A novel gene (retinovin) expressed selectively in the early stage of chick retinal development.

  title={A novel gene (retinovin) expressed selectively in the early stage of chick retinal development.},
  author={Masako Itami and Toshihiko Matsuo and Hiroshi Ohtsuki},
  journal={Biochemical and biophysical research communications},
  volume={276 1},
To understand molecular mechanisms of retinal development, genes expressed selectively only in the early stage of retinal development were isolated by subtractive hybridization based on suppression polymerase chain reaction. The retina has no layered structure in 7-day chick embryos, in contrast with the fully developed multilayered structure of neurons in 15-day embryos. The subtraction between cDNA derived from retinal tissues at these different stages, followed by repeat rounds of 5'-RACE… 
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    Proceedings of the National Academy of Sciences of the United States of America
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