A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity.

@article{MartinKillias2011ANF,
  title={A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity.},
  author={Patricia Martin-Killias and Nikolas Stefan and Sacha I. Rothschild and Andreas Pl{\"u}ckthun and Uwe Zangemeister-Wittke},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 1},
  pages={100-10}
}
PURPOSE Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the limitations of antibodies for biomedical applications. Here, we assessed the potential of an epithelial cell adhesion molecule (EpCAM)-specific DARPin (Ec4) for tumor targeting as a fusion toxin with Pseudomonas aeruginosa exotoxin A. EXPERIMENTAL DESIGN DARPin Ec4 was genetically fused to a truncated form of Pseudomonas aeruginosa exotoxin A (ETA″) and expressed in… CONTINUE READING

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