A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis.

@article{Mellin2007ANF,
  title={A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis.},
  author={Jeffery R Mellin and Sulip Goswami and Susan Grogan and Brian Tjaden and Caroline Attardo Genco},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 10},
  pages={3686-94}
}
Iron is both essential for bacterial growth and toxic at higher concentrations; thus, iron homeostasis is tightly regulated. In Neisseria meningitidis the majority of iron-responsive gene regulation is mediated by the ferric uptake regulator protein (Fur), a protein classically defined as a transcriptional repressor. Recently, however, microarray studies have identified a number of genes in N. meningitidis that are iron and Fur activated, demonstrating a new role for Fur as a transcriptional… CONTINUE READING

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