A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.

@article{Wang2008ANF,
  title={A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.},
  author={Meilin Wang and Zhizhong Zhang and Haixia Zhu and Guangbo Fu and Shouyu Wang and Dongmei Wu and Jianwei Zhou and Qingyi Wei and Zhengdong Zhang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 11},
  pages={3633-40}
}
PURPOSE MDM2 is believed to regulate the p53 level in modulating DNA repair, cell cycle control, cell growth, and apoptosis. We hypothesize that genetic variants in the MDM2 gene are associated with risk of bladder cancer. EXPERIMENTAL DESIGN We first conducted a case-control study of 234 bladder cancer cases and 253 cancer-free controls, using the haplotype-based tagging single nucleotide polymorphism (SNP) approach involving 13 common SNPs initially identified in 100 control subjects. We… CONTINUE READING