A novel functional human eukaryotic translation initiation factor 4G.

  title={A novel functional human eukaryotic translation initiation factor 4G.},
  author={Alessandra Gradi and Hiroaki Imataka and Yuri V. Svitkin and Eran Rom and Brian Raught and Shigenobu Morino and Nahum Sonenberg},
  journal={Molecular and cellular biology},
  volume={18 1},
Mammalian eukaryotic translation initiation factor 4F (eIF4F) is a cap-binding protein complex consisting of three subunits: eIF4E, eIF4A, and eIF4G. In yeast and plants, two related eIF4G species are encoded by two different genes. To date, however, only one functional eIF4G polypeptide, referred to here as eIF4GI, has been identified in mammals. Here we describe the discovery and functional characterization of a closely related homolog, referred to as eIF4GII. eIF4GI and eIF4GII share 46… CONTINUE READING


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