A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.

@article{Murphy2003ANF,
  title={A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.},
  author={James M Murphy and Sally C. Ford and Ursula M Wiedemann and Paul Carr and David L. Ollis and Ian G. Young},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={10572-7}
}
The receptors for human interleukins 3 and 5 and granulocyte macrophage colony-stimulating factor are composed of ligand-specific alpha-subunits and a common beta-subunit (betac), the major signaling entity. The way in which betac interacts with ligands in the respective activation complexes has remained poorly understood. The recently determined crystal… CONTINUE READING