A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.

@article{Ajuh2002ANF,
  title={A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.},
  author={Paul M Ajuh and Janet Chusainow and Ursula Ryder and Angus I. Lamond},
  journal={The EMBO journal},
  year={2002},
  volume={21 23},
  pages={6590-602}
}
Human factor C1 (HCF-1) is needed for the expression of herpes simplex virus 1 (HSV-1) immediate-early genes in infected mammalian cells. Here, we provide evidence that HCF-1 is required for spliceosome assembly and splicing in mammalian nuclear extracts. HCF-1 interacts with complexes containing splicing snRNPs in uninfected mammalian cells and is a stable… CONTINUE READING