A novel function for Sam68: enhancement of HIV-1 RNA 3' end processing.

@article{McLaren2004ANF,
  title={A novel function for Sam68: enhancement of HIV-1 RNA 3' end processing.},
  author={Meredith Lee McLaren and Kengo Asai and Alan Cochrane},
  journal={RNA},
  year={2004},
  volume={10 7},
  pages={
          1119-29
        }
}
Both cis elements and host cell proteins can significantly affect HIV-1 RNA processing and viral gene expression. Previously, we determined that the exon splicing silencer (ESS3) within the terminal exon of HIV-1 not only reduces use of the adjacent 3' splice site but also prevents Rev-induced export of the unspliced viral RNA to the cytoplasm. In this report, we demonstrate that loss of unspliced viral RNA export is correlated with the inhibition of 3' end processing by the ESS3. Furthermore… CONTINUE READING

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