A novel form of presynaptic plasticity based on the fast reactivation of release sites switched off during low-frequency depression.

@article{Doussau2010ANF,
  title={A novel form of presynaptic plasticity based on the fast reactivation of release sites switched off during low-frequency depression.},
  author={Fr{\'e}d{\'e}ric Doussau and Yann Humeau and Fabio Benfenati and Bernard Poulain},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 49},
  pages={16679-91}
}
Repetitive firing of neurons at a low frequency often leads to a decrease in synaptic strength. The mechanism of this low-frequency depression (LFD) is poorly understood. Here, LFD was studied at Aplysia cholinergic synapses. The absence of a significant change in the paired-pulse ratio during LFD, together with the facts that neither the time course nor the extent of LFD were affected by the initial release probability, suggests that LFD is not related to a depletion of the ready-to-fuse… CONTINUE READING

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