A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

@article{McDowall2003ANF,
  title={A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.},
  author={Alison McDowall and David Inwald and Birgit Leitinger and Alison E Jones and Ri J Liesner and Nigel Klein and Nancy Hogg},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 1},
  pages={51-60}
}
The adhesion receptors known as integrins perform key functions for hematopoietic cells. The platelet integrin alphaIIbbeta3 is critical in hemostasis, and the beta1 and beta2 integrins on leukocytes have many roles in cell-mediated immunity. Mutations in the beta2 subunit lead to integrin nonexpression and to an immune deficiency, leukocyte adhesion deficiency-1. Mutations in either the alpha or beta subunit of alphaIIbbeta3 usually lead to integrin nonexpression and a bleeding tendency termed… CONTINUE READING

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