A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.

@article{OConnell2006ANF,
  title={A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.},
  author={Peta J O'Connell and Xiangbin Wang and Matilde Le{\'o}n-Ponte and Corrie Griffiths and Sandeep C. Pingle and Gerard P. Ahern},
  journal={Blood},
  year={2006},
  volume={107 3},
  pages={1010-7}
}
Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cells. DCs take up 5-HT from the microenvironment and from activated T cells (that synthesize 5-HT) and this uptake is inhibited by the antidepressant, fluoxetine. Expression of 5-HT… CONTINUE READING
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