A novel fibronectin type III module binding motif identified on C-terminus of Leptospira immunoglobulin-like protein, LigB.

@article{Lin2009ANF,
  title={A novel fibronectin type III module binding motif identified on C-terminus of Leptospira immunoglobulin-like protein, LigB.},
  author={Y Lin and Alex I. Greenwood and Weiwei Yan and Linda K Nicholson and Yogendra Sharma and S P Mcdonough and Yuwei Chang},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={389 1},
  pages={57-62}
}
Infection by pathogenic strains of Leptospira hinges on the pathogen's ability to adhere to host cells via extracellular matrix such as fibronectin (Fn). Previously, the immunoglobulin-like domains of Leptospira Lig proteins were recognized as adhesins binding to N-terminal domain (NTD) and gelatin binding domain (GBD) of Fn. In this study, we identified another Fn-binding motif on the C-terminus of the Leptospira adhesin LigB (LigBCtv), residues 1708-1712 containing sequence LIPAD with a beta… CONTINUE READING

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