A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (Barnett´s pitviper) snake venom with anti-platelet properties.

@article{Sanchez2016ANF,
  title={A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (Barnett´s pitviper) snake venom with anti-platelet properties.},
  author={El{\'a}dio Oswaldo Flores Sanchez and Michael Richardson and Luiza Helena Gremski and Silvio Sanches Veiga and Armando Yarlequ{\'e} and Stephan Niland and Augusto Martins Lima and Maria In{\'a}cia Estev{\~a}o-Costa and Johannes A Eble},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1860 3},
  pages={542-56}
}
BACKGROUND Viperid snake venoms contain active components that interfere with hemostasis. We report a new P-I class snake venom metalloproteinase (SVMP), barnettlysin-I (Bar-I), isolated from the venom of Bothrops barnetti and evaluated its fibrinolytic and antithrombotic potential. METHODS Bar-I was purified using a combination of molecular exclusion and cation-exchange chromatographies. We describe some biochemical features of Bar-I associated with its effects on hemostasis and platelet… CONTINUE READING
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