A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.

  title={A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.},
  author={Barbara Barylko and Stefan H. Gerber and Derk D Binns and Nikolai Grichine and Mikhail Khvotchev and Thomas C S{\"u}dhof and Joseph P Albanesi},
  journal={The Journal of biological chemistry},
  volume={276 11},
Phosphatidylinositolpolyphosphates (PIPs) are centrally involved in many biological processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. Phosphorylation of phosphatidylinositol at the D-4 position, an essential step in the biosynthesis of PIPs, appears to be catalyzed by two biochemically distinct enzymes. However, only one of these two enzymes has been molecularly characterized. We now describe a novel class of phosphatidylinositol 4-kinases… CONTINUE READING

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