A novel family of negative and positive allosteric modulators of NMDA receptors.

@article{Costa2010ANF,
  title={A novel family of negative and positive allosteric modulators of NMDA receptors.},
  author={Blaise Mathias Costa and Mark W. Irvine and Guangyu Fang and Richard J. Eaves and Marie Belen Mayo-Martin and Donald A. Skifter and David Edward Jane and Daniel T Monaghan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={335 3},
  pages={
          614-21
        }
}
The N-methyl-D-aspartate (NMDA) receptor family regulates various central nervous system functions, such as synaptic plasticity. However, hypo- or hyperactivation of NMDA receptors is critically involved in many neurological and psychiatric conditions, such as pain, stroke, epilepsy, neurodegeneration, schizophrenia, and depression. Consequently, subtype-selective positive and negative modulators of NMDA receptor function have many potential therapeutic applications not addressed by currently… CONTINUE READING

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